![]() ![]() Dynamic covalent chemistry enables formation of antimicrobial peptide quaternary assemblies in a completely abiotic manner. Designing helical molecular capsules based on folded aromatic amide oligomers. Sequence programmable peptoid polymers for diverse materials applications. Solid-phase synthesis of sequence-defined informational oligomers. Recent developments in solid-phase strategies towards synthetic, sequence-defined macromolecules. Synthesis of non-natural sequence-encoded polymers using phosphoramidite chemistry. Oligonucleotide synthesis on a polymer support. ![]() ![]() Synchronization of two assembly processes to build responsive DNA nanostructures. Complex DNA nanostructures from oligonucleotide ensembles. Folding DNA to create nanoscale shapes and patterns. Nanoparticle superlattice engineering with DNA. DNA and RNA can be equally efficient catalysts for carbon-carbon bond formation. A catalytic DNA for porphyrin metallation. DNA-templated organic synthesis and selection of a library of macrocycles. The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules. The structural characterization of oligonucleotide-modified gold nanoparticle networks formed by DNA hybridization. A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin. The design of coiled-coil structures and assemblies. Sequence-controlled polymerizations: the next Holy Grail in polymer science? Polym. In this Review Article, we discuss synthetic platforms that produce sequence-defined, duplex-forming oligomers of varying length, strength and association mode, and highlight several analytical techniques used to characterize their hybridization. ![]() Developing sequence-defined polymers that are specific for their complementary sequence and achieve their desired binding strengths is critical for producing increasingly complex structures for new functional materials. Selectivity can be attained by tuning the monomer sequence, thereby creating the need for chemical platforms that can produce sequence-defined polymers at scale. These sequence-defined polymers can assemble into discrete structures, such as molecular duplexes, via reversible interactions between functional groups. Sequence-defined polymers take inspiration from biology by using chain length and monomer sequence as handles for tuning structure and function. The rapid speed of sequencing attained with modern technology has been instrumental in obtaining complete DNA sequences, or genomes, of numerous types and species of life, including the human genome and those of other animal, plant, and microbial species.Creating the next generation of advanced materials will require controlling molecular architecture to a degree typically achieved only in biopolymers. Knowledge of DNA sequences has become indispensable for basic biological research, and in numerous applied fields such as diagnostics, biotechnology, forensic biology, and biological systematics. Rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. The (c) major and minor grooves are binding sites for DNA binding proteins during processes such as transcription (the copying of RNA from DNA) and replication.ĭNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. \( \newcommand\): DNA Structure: DNA has (a) a double helix structure and (b) phosphodiester bonds. ![]()
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